◆ 个人简介
陈知远：理学博士，教授，博士生导师。中国化学会会员。
联系方式： zchen@jxnu.edu.cn 或者 zhiyuan_66@qq.com
◆ 教育经历
2011.07 - 至今，威廉希尔中国官网，有机化学教研室工作；
2012.08 – 2013.08，南洋理工大学（NTU，新加坡）化学与生物化学部，博士后；
2008.09 - 2011.06，复旦大学化学系有机化学专业学习，理学博士学位；
2006.07 - 2008.08，上海药明康德新药开发有限公司化学合成部研究员；
2003.09 - 2006.06，武汉大学化学与分子科学学院有机化学专业学习，理学硕士；
1999.09 - 2003.06，华中农业大学理学院学习，理学学士。
◆ 承担的科研项目情况
国家自然科学基金面上项目（2016NSFC，主持在研）；
国家自然科学基金地区基金项目（2014NSFC，主持在研）；
江西省自然科学基金面上项目（主持在研）；
国家自然科学基金青年科学基金项目（2012NSFC，已结题）；
教育部高等学校博士学科点专项科研基金联合项目（2013，已结题）；
江西省自然科学基金（已结题）；
威廉希尔娱乐青年英才支持项目（已结题）；
江西省教育厅科学基金（已结题）；
威廉希尔娱乐博士启动基金（已结题）。
◆ 研究方向与兴趣
金属有机化学；有机合成；新药与新材料技术研发。
◆ 科研和教学业绩
主持（完成）国家级课题3项，省部级课题4项。作为一作或通讯作者在国际主流学术期刊上发表SCI论文40余篇，其中影响因子IF大于4.0的高水平学术论文24篇，先后有6篇论文被国际著名的化学评论期刊Synfacts评为亮点文章（highlight）而加以报道。获批中国发明授权专利3项。课题组毕业的研究生中先后有两人次获得江西省优秀硕士学位论文，三人次获得威廉希尔娱乐优秀硕士学位论文。目前承担本科生《基础有机化学》（上，下）、《基础有机化学实验I, II》，研究生《有机催化》、《有机化合物结构分析》等课程。先后获得的奖励包括江西省高等学校科技成果奖二等奖（2013年），上海市研究生博士学位论文优秀成果奖（2013年），复旦大学优秀博士学位论文（2012年），复旦大学优秀毕业生（2011年），礼来（Eli Lilly）公司亚洲区杰出论文一等奖（2011年），陶氏化学（Dow）公司合成奖两次（2009年，2010年）等。
◆ 发表的学术成果
[46] Hao Zhou, Jianquan Hong, Jiapian Huang, and Zhiyuan Chen.* Metal-free Synthesis of Unsymmetrical Sulfoximine Ureas: A Highly Efficient Curtius Rearrangement Approach. 2017, manuscript under review.
[45] Jiapian Huang, Yangfei Huang, Tao Wang, Qin Huang, Zhihua Wang, Zhiyuan Chen.* Microwave-assisted Cp*CoIII-Catalyzed C-H Activation/Double C-N Bond Formation Reactions to Thiadiazine-1-oxides, Organic Letters, 2017, 19, 1128-1131. 【影响因子IF= 6.732】
[44] Hui Zhu, and Zhiyuan Chen.* DDQ-Mediated Oxidative Radical Cycloisomerization of 1,5-Diynols: Regioselective Synthesis of Benzo[b]fluorenones under Metal-Free Conditions. Organic Letters, 2016, 16, 488-491. 【影响因子IF= 6.732】
[43] Jiapian Huang, Yi Yang, and Zhiyuan Chen.* Rh(II)-Catalyzed Regioselective Carbenoid Insertion Reaction of Simple Indoles with N-Sulfonyltriazoles: A Rapid Access to Tryptamine Vinylogues. Advanced Synthesis & Catalysis, 2016. 358, 201-206. 【影响因子IF= 6.453】
[42] Jiapian Huang, Zhiyuan Chen,* Zhijie Wang.* Transition-Metal-Catalyzed Hydrosulfoximination and Oxidation Reaction for the Synthesis of Sulfoximine Derivatives. The Journal of Organic Chemistry, 2016, 81, 9308-9314. 【影响因子IF= 4.785】
[41] Jiapian Huang, Zhiyuan Chen,* Jianjun Yuan, Yiyuan Peng.* Recent Advances in Highly Selective Applications of Nitroso Compounds. Asian Journal of Organic Chemistry, 2016, 5, 951-960. 【影响因子IF= 3.275】
[40] Zhiyuan Chen,* Xingping Zeng, Bingyu Yan, Yanlu Zhao, Yang Fu.* Gold-catalyzed Intramolecular Annulations Toward Fused Tricyclic [1,3]Oxazino[3,4-a]indol-1-ones under Extremely Mild Conditions. RSC Advances. 2015. 357, 100251-100255. 【影响因子IF= 3.289】
[39] Jiapian Huang, Hao, Zhou, Zhiyuan Chen.* 基于三氮唑类化合物的金属卡宾形成反应研究进展, Chinese Journal of Organic Chemistry, 2016, 36, 1555-1521.
[38] Xiumei Wang, Mingfan Liu,* Zhiyuan Chen.* Brønsted-acid catalyzed cascade annulations toward the fused pyranoquinoline derivatives. Tetrahedron, 2016, 72, 4423-4426. 【影响因子IF= 2.645】
[37] Hui Zhu, Jiapian Huang, Congbin Fan, and Zhiyuan Chen.* Platinum-Catalyzed Cascade Rearrangement Reaction of 1,5-Diynyl Esters: Unusual Regioselective 1,5-Hydride Migration. Chemistry - An Asian Journal, 2015, 10, 1463-1466. 【影响因子IF= 4.592】
[36] 朱辉, 叶长青, 陈知远.* 降冰片烯促进的钯催化多米诺Catellani反应研究进展. Chinese Journal of Organic Chemistry. 2015, 35, 2291-2300.
[35] 朱辉, 严冰玉, 曹杨, 陈知远.* 过渡金属催化的多炔基化合物高选择性亲电环异构化反应研究. Chinese Journal of Organic Chemistry. 2015, 35, 509-521.（Invited ACCOUNT for the organometallic special issue.）
[34] Zhiyuan Chen,* Changqing Ye, Hui Zhu, Xingping Zeng, Jianjun Yuan. Palladium/Norbornene-Mediated Tandem C-H Amination/C-I Alkenylation Reaction of Aryl Iodide with Secondary Cyclic O-Benzoyl Hydroxylamine and Activated Terminal Olefin, Chemistry - A European Journal, 2014, 20, 4237-4241. 【影响因子IF= 5.771】
[33] Qing Xiao, Hui Zhu, Guangming Li,* Zhiyuan Chen.* Synthesis of Trifluoromethanesulfanyl Benzofulvenes via a Cascade Electrophilic Cyclization under Mild Conditions, Advanced Synthesis & Catalysis, 2014. 356, 3809-3815.
[32] Zhiyuan Chen,* Xuegong Jia, Jiapian Huang, Jianjun Yuan. Platinum-Catalyzed Tandem Cycloisomerization Reaction of Benzoendiynyl Esters: Regioselective Long-Range 1,5-Acyl Migration. The Journal of Organic Chemistry, 2014. 79, 10674-10681.
[31] Changqing Ye, Hui Zhu, Zhiyuan Chen.* Synthesis of Biaryl Tertiary Amines through Pd/Norbornene Joint Catalysis in a Remote C−H Amination/Suzuki Coupling Reaction. The Journal of Organic Chemistry, 2014. 79, 8900-8905. Highlighted in Synfacts, 2014, 10, 1151.
[30] Yuewen Li, Liang Gao, Hui Zhu, Guangming Li,* Zhiyuan Chen.* Silver Triflate and Triflic Anhydride-Promoted Expedient Synthesis of Acylated 1-Aminoisoquinolines, Organic Biomolecular Chemistry, 2014, 12, 6982-6985.
[29] Tao Wang,* Rou Li, Danhong Yu, Chenghao Gu, Fei Xiong,* and Zhiyuan Chen,* Synthesis of 1-Aminoisoquinolines via the Coinage Metal Cocatalyzed Reaction of 2-Alkynylbenzaldoximes with Isocyanoacetates, Synthesis, 2014, 46, 3213-3220.
[28] 叶长青，陈知远*，钯催化的远程碳氢键胺化反应合成联芳基叔胺，中国科技论文，2014, 201409-161.
[27] 叶长青，朱辉，陈知远*，醋酸钯和降冰片烯介导的多组分C-H键胺化/C-X键烯化反应，中国科技论文，2014, 201401-977.
[26] Zhiyuan Chen,* Xuegong Jia, Changqing Ye, Guanyinsheng Qiu, and Jie Wu.* AgOTf-Catalyzed Electrophilic Cyclization of Triynols with NXS: Rapid Synthesis of Densely Trisubstituted Naphthalenes and Quinolines, Chemistry - An Asian Journal, 2014, 9, 126-130.
[25] Qing Xiao, Jie Sheng, Zhiyuan Chen,* Jie Wu.* Generation of 4-((Trifluoro- methyl)thio)-2H-benzo[e][1,2]thiazine 1,1-Dioxides via a Reaction of Trifluoromethanesulfanylamide with 2-(2-Alkynyl)benzenesulfonamide, Chemical Communications, 2013, 49, 8647-8649. 【影响因子IF= 6.567】
[24] Zhiyuan Chen, Beili Lu, Zhenhua Ding, Ke Gao, Naohiko Yoshikai.* α-Palladation of Imines as Entry to Dehydrogenative Heck Reaction: Aerobic Oxidative Cyclization of N-Allylimines to Pyrroles, Organic Letters, 2013, 15, 1966-1969. Highlighted in Synfacts, 2013, 931.
[23] Zhiyuan Chen,* Mengjing Zeng, Jianjun Yuan, Qin Yang, Yiyuan Peng.* Novel Silver Tetrafluoroborate Catalyzed Electrophilic Cascade Cyclization Reaction: A Facile Approach to the Synthesis of Halo-Substituted Benzo[a]fluorenols, Organic Letters, 2012, 14, 3588-3591.
[22] Zhiyuan Chen,* Liang Gao, Shengqing Ye, Qiuping Ding, Jie Wu.* Silver Triflate-copper(II) Acetate Cooperative Catalysis in a Cascade Reaction for Concise Synthesis of 2-Carbonyl H-pyrazolo[5,1-a]isoquinolines, Chemical Communications, 2012, 48, 3975-3977.
[21] Ping Huang, Zhiyuan Chen,* Qin Yang, Yiyuan Peng.* Silver Triflate and Palladium Acetate Co-catalyzed Reaction of N'-(2-Alkynylbenzylidene)hydrazide with N-Allyl Ynamide, Organic Letters, 2012, 14, 2790-2793.
[20] Ping Huang, Qin Yang, Zhiyuan Chen,* Qiuping Ding, Jingshi Xu, Yiyuan Peng.* Metal Co-catalyzed Tandem Alkynylative Cyclization Reaction of in Situ Formed N-Iminoisoquinolinium Ylides with Bromoalkynes via C-H Bond Activation, The Journal of Organic Chemistry, 2012, 77, 8092-8098. Highlighted in Synfacts, 2012, 8, 1305.
[19] Chao Ye, Zhiyuan Chen,* Huanhuan Wang, Jie Wu.* Generation of Diverse 1-(Isoquinolin-1-yl)guanidines via a Sequential Multi-component/Cross-coupling Reaction, Tetrahedron 2012, 68, 5197-5202.
[18] Liang Gao, Shengqing Ye, Qiuping Ding, Zhiyuan Chen,* and Jie Wu.* An Efficient Approach to H-pyrazolo[5,1-a]isoquinolines via a Silver Triflate-Catalyzed Reaction of N'-(2-Alkynylbenzylidene)hydrazide With Allenoate, Tetrahedron 2012, 68, 2765-2769.
[17] Zhiyuan Chen, Chao Ye, Liang Gao, Jie Wu.* Diversity-oriented Approach to 1,2-Dihydroisoquinolin-3(4H)-imines via Copper(I)-catalyzed Reaction of (E)-2-Ethynylphenylchalcone, Sulfonyl azide, and Amine. Chemical Communications, 2011, 47, 5623-5625.
[16] Zhiyuan Chen, Danqing Zheng, Jie Wu.* A Facile Route to Polysubstituted Indoles via Three-component Reaction of 2-Ethynylaniline, Sulfonyl Azide, and Nitroolefin. Organic Letters, 2011. 13, 848-851. Highlighted by Synfacts, 2011, 6, 655.
[15] Zhiyuan Chen, Xiaolin Pan, Jie Wu.* A Facile Route to Diverse H-Pyrazolo[5,1-a]isoquinolines via Sequential Reaction of N'-(2-Alkynylbenzylidene)hydrazide. Synlett, 2011, 7, 964-968.
[14] Danqing Zheng, Zhiyuan Chen, Jie Wu.* An Efficient Route to 1-Aminoisoquinolines via AgOTf-catalyzed Reaction of 2-Alkynylbenzaldoxime with Amine. Organic Biomolecular Chemistry, 2011, 9, 4763-4765.
[13] Zhiyuan Chen, Xingxin Yu, Jie Wu.* Silver Triflate and N-heterocyclic Carbene Co-catalyzed Reaction of N’-(2-Alkynyl-benzylidene)hydrazide, Methanol with α, β- unsaturated aldehyde. Chemical Communications, 2010, 46, 6356-6358.
[12] Zhiyuan Chen, Jie Wu.* Efficient Generation of Biologically Active H-Pyrazolo[5, 1-a]isoquinolines via Multicomponent Reaction. Organic Letters, 2010, 12, 4856-4859.
[11] Xingxin Yu, Zhiyuan Chen, Xiaodi Yang, Jie Wu.* Tandem Reactions of N’-(2-Alkynylbenzylidene)hydrazides with Silyl Enolates: A Facile Route to H-Pyrazolo[5, 1-a]isoquinolines. Journal of Combinatorial Chemistry, 2010, 12, 374-378.
[10] Zhiyuan Chen, Xingxin Yu, Mingchao Su, Jie Wu.* Multicatalytic Tandem Reactions of 2-Alkynylbenzaldoximes with Isocyanides. Advanced Synthesis & Catalysis, 2009, 351, 2702-2709. Highlighted in Synfacts, 2010, 2, 150.
[9] Zhiyuan Chen, Qiuping Ding, Xingxin Yu, Jie Wu.* Silver Triflate-catalyzed or Electrophile-mediated Tandem Reaction of N’-(2- Alkynylbenzylidene)hydrazides with Dimethyl Acetylenedicarboxylate. Advanced Synthesis & Catalysis, 2009, 351, 1692-1698. Highlighted in Synfacts, 2009, 10, 1083.
[8] Zhiyuan Chen, Xiaodi Yang, Jie Wu.* AgOTf-catalyzed Tandem Reaction of N’-(2-Alkynylbenzylidene)hydrazide with Alkyne. Chemical Communications, 2009, 45, 3469-3471.
[7] Zhiyuan Chen, Mingchao Su, Xingxin Yu, Jie Wu.* Synthesis of Functionalized H-Pyrazolo[5,1-a]isoquinolines via Sequential Reactions of N’-(2-Alkynylbenzylidene)hydrazides. Organic Biomolecular Chemistry, 2009, 7, 4641-4646.
[6] Qiuping Ding, Zhiyuan Chen, Xingxin Yu, Yiyuan Peng,* Jie Wu.* Highly Efficient Electrophilic Cyclization of N’-(2-Alkynylbenzylidene)- hydrazides. Tetrahedron Letters, 2009, 50, 340-342.
[5] Xingxin Yu, Qiuping Ding, Zhiyuan Chen, Jie Wu.* Lewis Acid-catalyzed Reactions of N’-(2-Alkynylbenzylidene)hydrazides with Diethyl Phosphate. Tetrahedron Letters, 2009, 50, 4279-4282.
[4] Caimao Zhan,* Zhiyuan Chen, Weibin Bai, Xi Yang. Green Light-emitting Region-regular Poly(9,9-Dihexylfluorene-co-Fluorenone) Prepared from Solvent-free Oxidative Coupling Polymerization. Wuhan University Journal of Natural Sciences, 2007, 12, 327-332.
[3] Yanzhao Cheng, Guojia Fang,* Chun Li, Longyan Yuan, Lei Ai, Bingruo Chen, Xingzhong Zhao, Zhiyuan Chen, Weibin Bai, Caimao Zhan.* Fabrication and Electrical, Photosensitive Properties of p-Poly(9,9-diethylfluo-rene)/n-silicon Nanowire Heterojunction. Journal of Applied Physics, 2007, 102, 83516.
[2] 陈知远，白卫兵，詹才茂*， 聚芴材料低能级发射现象及其机理研究现状，高分子通报, 2007, 8, 11-17.
[1] Weibin Bai, Zhiyuan Chen, Caimao Zhan.* Emitting Stability of Poly(9,9-dialkyl- fluorene-co-N-butylcarbazole) by Solid-state Oxidative Coupling Polymerization. Chinese Chemical Letters, 2007, 18, 76-78.
◆ 获批授权中国发明专利三项
[1] 授权专利：陈知远，朱辉，黄家翩；一种1-亚苄基-2-烯基-3-茚酯系列化合物的制备方法，授权专利号：ZL 201510030772.4.
[2]. 授权专利：陈知远，贾学功，叶长青；一种3-卤代-2-炔基-1-酮基萘系列化合物的制备方法，授权专利号：ZL 201310080532.6.
[3]. 授权专利：陈知远，曾梦静，杨琴，彭以元；一种苯并[a]芴醇的制备方法，授权专利号：ZL 201210144087.0.
[4] 陈知远，周豪，王秀梅，一种亚砜亚磺酰基脲系列化合物的高效率制备方法，专利号: 201710051723.8.
[5] 陈知远，黄家翩，彭以元，一种1-芳（烷）基苯并[e][1,2,4]噻二唑-1-氧系列化合物的制备方法，专利号: 201610905924.5.
[6] 中国专利：陈知远，朱辉，彭以元，杨琴；一种绿色荧光材料苯并[b]芴酮系列化合物的快捷制备方法，专利号：201510700797.0.
[7] 陈知远，曾星平，彭以元，袁建军；一种具有新型结构的噁嗪并吲哚酮系列化合物的快捷制备方法，专利号：201510387436.5.
[8] 黄萍，陈知远，彭以元；一种2-烯丙基氨基吡唑并[5,1-a]异喹啉系列化合物的制备方法，专利号：201210133455.1.
[9] 陈知远，吴劼；2-氨基-1, 2-二氢异喹啉化合物的制备方法,专利号：201010127880.0.
[10] 詹才茂，陈知远，白卫兵, 一种绿光发射材料聚烷基芴的制备方法，专利号：200610018736.7。
